TMEM100

Entrez Summary: N/A
UniProt Summary: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. {ECO:0000250|UniProtKB:Q9CQG9}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mdivi-1 15μM R05 exp217	1.89
Nocodazole 0.2μM R00 exp24	1.9

arterial endothelial cell differentiation
blood vessel endothelial cell differentiation
positive regulation of vasculogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
regulation of vasculogenesis
positive regulation of endothelial cell differentiation
endocardial cushion formation
cardiac epithelial to mesenchymal transition
regulation of endothelial cell differentiation
endocardial cushion morphogenesis
protein kinase B signaling
regulation of sensory perception of pain
regulation of sensory perception
endocardial cushion development
mesenchyme morphogenesis
positive regulation of epithelial cell differentiation
vasculogenesis
epithelial to mesenchymal transition
endothelial cell differentiation
BMP signaling pathway
endothelium development
regulation of calcium-mediated signaling
cellular response to BMP stimulus
response to BMP
Notch signaling pathway
perikaryon
regulation of nervous system process
regulation of epithelial cell differentiation
mesenchymal cell differentiation
positive regulation of vasculature development
transmembrane receptor protein serine/threonine kinase signaling pathway
mesenchyme development
heart morphogenesis
angiogenesis
regulation of vasculature development
in utero embryonic development
blood vessel morphogenesis
blood vessel development
cellular response to growth factor stimulus
vasculature development