TMEM129

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. {ECO:0000269|PubMed:24807418}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CVT-10216 0.1μM R06 exp278	-1.99
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.9

endoplasmic reticulum to cytosol transport
retrograde protein transport, ER to cytosol
protein exit from endoplasmic reticulum
ubiquitin-dependent ERAD pathway
ERAD pathway
response to unfolded protein
response to topologically incorrect protein
ubiquitin protein ligase activity
response to endoplasmic reticulum stress
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
intracellular protein transport
response to organonitrogen compound
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular response to stress
organic substance catabolic process
cellular catabolic process