TMEM138

Gene Information
  • Official Symbol: TMEM138
  • Official Name: transmembrane protein 138
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 51524
  • UniProt: Q9NPI0
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].
  • UniProt Summary: Required for ciliogenesis. {ECO:0000269|PubMed:22282472}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 10669
  • Expression level (log2 read counts): 5.74

Expression Distribution

  • Last modified: 2026/01/07 22:37
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