TMEM225

Entrez Summary: N/A
UniProt Summary: Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. {ECO:0000250|UniProtKB:Q9D9S2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acrosomal membrane
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of catalytic activity
negative regulation of molecular function
regulation of hydrolase activity
regulation of phosphate metabolic process
regulation of phosphorus metabolic process