TMF1 [The Human Chemical-Genetic Interaction Map Project]

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======= TMF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMF1
  * **<color #00a2e8>Official Name</color>**: TATA element modulatory factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7110|7110]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P82094|P82094]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601126|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TMF TATA bd|
|TMF DNA bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of testosterone secretion|
|regulation of testosterone secretion|
|luteinizing hormone secretion|
|gonadotropin secretion|
|Leydig cell differentiation|
|endocrine hormone secretion|
|acrosome assembly|
|spermatid nucleus differentiation|
|secretory granule organization|
|endocrine process|
|positive regulation of lipid transport|
|sperm motility|
|flagellated sperm motility|
|hormone secretion|
|hormone transport|
|positive regulation of lipid localization|
|transcription coregulator activity|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|cellular component assembly involved in morphogenesis|
|regulation of lipid transport|
|positive regulation of hormone secretion|
|nucleus organization|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of lipid localization|
|spermatid development|
|spermatid differentiation|
|male sex differentiation|
|signal release|
|regulation of proteasomal protein catabolic process|
|gonad development|
|development of primary sexual characteristics|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|germ cell development|
|sex differentiation|
|regulation of hormone secretion|
|vesicle organization|
|defense response to bacterium|
|cellular process involved in reproduction in multicellular organism|
|regulation of protein catabolic process|
|positive regulation of secretion by cell|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|positive regulation of cytokine production|
|transcription by RNA polymerase II|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|spermatogenesis|
|male gamete generation|
|Golgi membrane|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|response to bacterium|
|gamete generation|
|regulation of cytokine production|
|regulation of proteolysis|
|regulation of secretion by cell|
|organelle assembly|
|regulation of secretion|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|DNA binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.97|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.77|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.77|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.71|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11261
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMF1 Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>