TMF1

Entrez Summary: N/A
UniProt Summary: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TMF TATA bd
TMF DNA bd

positive regulation of testosterone secretion
regulation of testosterone secretion
luteinizing hormone secretion
gonadotropin secretion
Leydig cell differentiation
endocrine hormone secretion
acrosome assembly
spermatid nucleus differentiation
secretory granule organization
endocrine process
positive regulation of lipid transport
sperm motility
flagellated sperm motility
hormone secretion
hormone transport
positive regulation of lipid localization
transcription coregulator activity
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
cellular component assembly involved in morphogenesis
regulation of lipid transport
positive regulation of hormone secretion
nucleus organization
male gonad development
development of primary male sexual characteristics
regulation of lipid localization
spermatid development
spermatid differentiation
male sex differentiation
signal release
regulation of proteasomal protein catabolic process
gonad development
development of primary sexual characteristics
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
germ cell development
sex differentiation
regulation of hormone secretion
vesicle organization
defense response to bacterium