TMOD3

Entrez Summary: N/A
UniProt Summary: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 1μM R06 exp286	1.76
DABN 20μM R00 exp17	1.82

pointed-end actin filament capping
tropomyosin binding
striated muscle thin filament
cadherin binding involved in cell-cell adhesion
myofibril
erythrocyte development
actin filament capping
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
myeloid cell development
negative regulation of protein depolymerization
negative regulation of protein polymerization
myofibril assembly
negative regulation of protein complex disassembly
positive regulation of mitotic cell cycle phase transition
erythrocyte differentiation
regulation of protein depolymerization
erythrocyte homeostasis
positive regulation of cell cycle phase transition
cellular component assembly involved in morphogenesis
cell-cell adherens junction
myeloid cell homeostasis
regulation of protein complex disassembly
actomyosin structure organization
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
striated muscle cell development
negative regulation of cytoskeleton organization
muscle cell development
positive regulation of mitotic cell cycle
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
homeostasis of number of cells
striated muscle cell differentiation
myeloid cell differentiation
regulation of protein polymerization
muscle cell differentiation
muscle contraction