TNF
Gene Information
- Official Symbol: TNF
- Official Name: tumor necrosis factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 7124
- UniProt: P01375
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].
- UniProt Summary: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.
Pfam Domains GO Terms
Pfam Domains
| TNF |
GO Terms
| positive regulation of leukocyte adhesion to arterial endothelial cell |
| negative regulation of branching involved in lung morphogenesis |
| positive regulation of translational initiation by iron |
| positive regulation of fractalkine biosynthetic process |
| chronic inflammatory response to antigenic stimulus |
| positive regulation of fractalkine production |
| regulation of fractalkine production |
| positive regulation of chronic inflammatory response to antigenic stimulus |
| regulation of blood microparticle formation |
| positive regulation of blood microparticle formation |
| regulation of leukocyte adhesion to arterial endothelial cell |
| regulation of fractalkine biosynthetic process |
| positive regulation of vitamin D biosynthetic process |
| positive regulation of superoxide dismutase activity |
| positive regulation of calcidiol 1-monooxygenase activity |
| positive regulation of removal of superoxide radicals |
| regulation of chronic inflammatory response to antigenic stimulus |
| negative regulation of alkaline phosphatase activity |
| regulation of translational initiation by iron |
| sequestering of triglyceride |
| negative regulation of bicellular tight junction assembly |
| positive regulation of chronic inflammatory response |
| positive regulation of vitamin metabolic process |
| regulation of superoxide dismutase activity |
| epithelial cell proliferation involved in salivary gland morphogenesis |
| positive regulation of humoral immune response mediated by circulating immunoglobulin |
| negative regulation of myosin-light-chain-phosphatase activity |
| receptor biosynthetic process |
| regulation of branching involved in lung morphogenesis |
| negative regulation of cytokine secretion involved in immune response |
| necroptotic signaling pathway |
| regulation of calcidiol 1-monooxygenase activity |
| positive regulation of fever generation |
| regulation of myosin-light-chain-phosphatase activity |
| endothelial cell apoptotic process |
| regulation of fever generation |
| positive regulation of response to reactive oxygen species |
| death-inducing signaling complex assembly |
| negative regulation of amyloid-beta clearance |
| regulation of vitamin D biosynthetic process |
| regulation of chronic inflammatory response |
| regulation of branching involved in salivary gland morphogenesis |
| cellular response to nicotine |
| regulation of alkaline phosphatase activity |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| regulation of removal of superoxide radicals |
| positive regulation of sphingolipid biosynthetic process |
| positive regulation of ceramide biosynthetic process |
| positive regulation of heat generation |
| regulation of humoral immune response mediated by circulating immunoglobulin |
| positive regulation of hormone biosynthetic process |
| chronic inflammatory response |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| activation of MAPKKK activity |
| positive regulation of podosome assembly |
| positive regulation of chemokine biosynthetic process |
| positive regulation of interleukin-8 biosynthetic process |
| positive regulation of hair follicle development |
| positive regulation of inflammatory response to antigenic stimulus |
| negative regulation of glucose import |
| positive regulation of hair cycle |
| regulation of heat generation |
| regulation of vitamin metabolic process |
| regulation of endothelial cell development |
| positive regulation of neuroinflammatory response |
| positive regulation of leukocyte adhesion to vascular endothelial cell |
| regulation of establishment of endothelial barrier |
| regulation of chemokine biosynthetic process |
| positive regulation of membrane protein ectodomain proteolysis |
| positive regulation of chemokine secretion |
| positive regulation of interleukin-6 biosynthetic process |
| positive regulation of amyloid-beta formation |
| positive regulation of glial cell proliferation |
| positive regulation of hormone metabolic process |
| regulation of ceramide biosynthetic process |
| negative regulation of morphogenesis of an epithelium |
| regulation of chemokine secretion |
| regulation of interleukin-8 biosynthetic process |
| positive regulation of calcineurin-mediated signaling |
| regulation of cytokine secretion involved in immune response |
| regulation of amyloid-beta clearance |
| regulation of podosome assembly |
| regulation of membrane lipid metabolic process |
| regulation of sphingolipid biosynthetic process |
| positive regulation of heterotypic cell-cell adhesion |
| positive regulation of calcineurin-NFAT signaling cascade |
| positive regulation of protein localization to cell surface |
| positive regulation of humoral immune response |
| negative regulation of glucose transmembrane transport |
| positive regulation of cellular response to oxidative stress |
| positive regulation of steroid biosynthetic process |
| leukocyte tethering or rolling |
| negative regulation of lipid storage |
| positive regulation of amyloid precursor protein catabolic process |
| regulation of leukocyte adhesion to vascular endothelial cell |
| positive regulation of response to oxidative stress |
| leukocyte adhesion to vascular endothelial cell |
| regulation of immunoglobulin secretion |
| astrocyte activation |
| regulation of hair follicle development |
| positive regulation of nitric-oxide synthase activity |
| regulation of bicellular tight junction assembly |
| response to salt stress |
| regulation of membrane protein ectodomain proteolysis |
| regulation of interleukin-6 biosynthetic process |
| negative regulation of cell junction assembly |
| negative regulation of lipid catabolic process |
| necroptotic process |
| inflammatory response to antigenic stimulus |
| regulation of inflammatory response to antigenic stimulus |
| positive regulation of mononuclear cell migration |
| negative regulation of myoblast differentiation |
| positive regulation of alcohol biosynthetic process |
| negative regulation of cytokine production involved in immune response |
| regulation of heterotypic cell-cell adhesion |
| positive regulation of osteoclast differentiation |
| positive regulation of monooxygenase activity |
| phagocytic cup |
| regulation of amyloid-beta formation |
| positive regulation of steroid metabolic process |
| regulation of hormone biosynthetic process |
| epithelial cell apoptotic process |
| programmed necrotic cell death |
| regulation of hair cycle |
| positive regulation of acute inflammatory response |
| salivary gland morphogenesis |
| lipid storage |
| microglial cell activation |
| regulation of glial cell proliferation |
| positive regulation of translational initiation |
| necrotic cell death |
| leukocyte activation involved in inflammatory response |
| positive regulation of interleukin-6 secretion |
| regulation of neuroinflammatory response |
| tumor necrosis factor receptor binding |
| salivary gland development |
| regulation of superoxide metabolic process |
| positive regulation of vascular smooth muscle cell proliferation |
| regulation of endothelial cell differentiation |
| regulation of amyloid precursor protein catabolic process |
| negative regulation of animal organ morphogenesis |
| regulation of calcineurin-NFAT signaling cascade |
| extrinsic apoptotic signaling pathway via death domain receptors |
| lipopolysaccharide-mediated signaling pathway |
| embryonic digestive tract development |
| regulation of calcineurin-mediated signaling |
| regulation of response to reactive oxygen species |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| negative regulation of production of molecular mediator of immune response |
| negative regulation of signal transduction in absence of ligand |
| astrocyte development |
| positive regulation of B cell mediated immunity |
| negative regulation of endothelial cell proliferation |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of protein complex disassembly |
| glial cell activation |
| regulation of protein localization to cell surface |
| regulation of hormone metabolic process |
| protein kinase B signaling |
| positive regulation of nitric oxide biosynthetic process |
| cellular extravasation |
| positive regulation of epidermis development |
| positive regulation of nitric oxide metabolic process |
| negative regulation of lipid localization |
| neuroinflammatory response |
| cortical actin cytoskeleton organization |
| negative regulation of interleukin-6 production |
| exocrine system development |
| negative regulation of osteoblast differentiation |
| positive regulation of calcium-mediated signaling |
| regulation of nitric-oxide synthase activity |
| osteoclast differentiation |
| regulation of acute inflammatory response |
| regulation of lipid storage |
| negative regulation of fat cell differentiation |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| regulation of mononuclear cell migration |
| cortical cytoskeleton organization |
| positive regulation of interleukin-8 production |
| response to nicotine |
| positive regulation of reactive oxygen species biosynthetic process |
| macrophage activation |
| regulation of vascular smooth muscle cell proliferation |
| regulation of endothelial cell apoptotic process |
| leukocyte cell-cell adhesion |
| regulation of B cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| positive regulation of oxidoreductase activity |
| regulation of myoblast differentiation |
| astrocyte differentiation |
| positive regulation of neuron apoptotic process |
| regulation of lipid catabolic process |
| regulation of monooxygenase activity |
| positive regulation of myeloid leukocyte differentiation |
| regulation of glucose import |
| positive regulation of protein localization to plasma membrane |
| positive regulation of chemokine production |
| regulation of nitric oxide biosynthetic process |
| regulation of morphogenesis of a branching structure |
| negative regulation of viral genome replication |
| regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of phosphoprotein phosphatase activity |
| positive regulation of protein localization to cell periphery |
| regulation of immunoglobulin production |
| positive regulation of interferon-gamma production |
| regulation of osteoclast differentiation |
| negative regulation of protein dephosphorylation |
| positive regulation of cytokine biosynthetic process |
| negative regulation of cytokine secretion |
| positive regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of phagocytosis |
| regulation of interleukin-8 production |
| cellular response to amino acid stimulus |
| I-kappaB kinase/NF-kappaB signaling |
| regulation of synaptic transmission, glutamatergic |
| positive regulation of gliogenesis |
| negative regulation of protein complex disassembly |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| positive regulation of JUN kinase activity |
| negative regulation of ossification |
| regulation of glucose transmembrane transport |
| regulation of cellular response to oxidative stress |
| regulation of alcohol biosynthetic process |
| positive regulation of organelle assembly |
| response to osmotic stress |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of chemokine production |
| regulation of tyrosine phosphorylation of STAT protein |
| regulation of epithelial cell apoptotic process |
| regulation of translational initiation |
| positive regulation of lipid biosynthetic process |
| JNK cascade |
| negative regulation of viral life cycle |
| negative regulation of lipid metabolic process |
| positive regulation of receptor signaling pathway via JAK-STAT |
| regulation of cytokine production involved in immune response |
| regulation of response to oxidative stress |
| positive regulation of smooth muscle cell proliferation |
| regulation of reactive oxygen species biosynthetic process |
| regulation of epidermis development |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| epithelial cell proliferation |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of JUN kinase activity |
| regulation of steroid biosynthetic process |
| positive regulation of receptor signaling pathway via STAT |
| regulation of cell junction assembly |
| positive regulation of myeloid cell differentiation |
| positive regulation of neuron death |
| regulation of viral genome replication |
| defense response to Gram-positive bacterium |
| positive regulation of interleukin-6 production |
| regulation of protein localization to plasma membrane |
| regulation of oxidoreductase activity |
| regulation of phagocytosis |
| positive regulation of reactive oxygen species metabolic process |
| regulation of calcium-mediated signaling |
| extrinsic apoptotic signaling pathway |
| negative regulation of viral process |
| gland morphogenesis |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of extrinsic apoptotic signaling pathway |
| protease binding |
| negative regulation of phosphatase activity |
| regulation of cytokine biosynthetic process |
| positive regulation of peptidyl-serine phosphorylation |
| receptor metabolic process |
| stress-activated MAPK cascade |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| glial cell development |
| regulation of NIK/NF-kappaB signaling |
| myeloid leukocyte differentiation |
| negative regulation of dephosphorylation |
| regulation of osteoblast differentiation |
| glucose metabolic process |
| regulation of protein complex disassembly |
| regulation of steroid metabolic process |
| regulation of protein localization to cell periphery |
| response to amino acid |
| regulation of gliogenesis |
| regulation of myeloid leukocyte differentiation |
| negative regulation of transmembrane transport |
| recycling endosome |
| regulation of phosphoprotein phosphatase activity |
| tumor necrosis factor-mediated signaling pathway |
| regulation of phosphatidylinositol 3-kinase signaling |
| negative regulation of immune effector process |
| regulation of fat cell differentiation |
| positive regulation of protein localization to membrane |
| negative regulation of epithelial cell proliferation |
| positive regulation of translation |
| positive regulation of leukocyte migration |
| regulation of endothelial cell proliferation |
| regulation of receptor signaling pathway via JAK-STAT |
| digestive tract development |
| negative regulation of protein secretion |
| regulation of smooth muscle cell proliferation |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte mediated immunity |
| regulation of receptor signaling pathway via STAT |
| regulation of peptidyl-serine phosphorylation |
| regulation of humoral immune response |
| regulation of lipid localization |
| positive regulation of small molecule metabolic process |
| positive regulation of inflammatory response |
| negative regulation of peptide secretion |
| positive regulation of JNK cascade |
| positive regulation of cytokine secretion |
| regulation of protein dephosphorylation |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| positive regulation of lipid metabolic process |
| regulation of epithelial cell differentiation |
| stress-activated protein kinase signaling cascade |
| digestive system development |
| response to glucocorticoid |
| regulation of viral life cycle |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| negative regulation of immune response |
| intrinsic apoptotic signaling pathway |
| regulation of lymphocyte mediated immunity |
| positive regulation of synaptic transmission |
| positive regulation of cellular amide metabolic process |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of extrinsic apoptotic signaling pathway |
| activation of MAPK activity |
| hexose metabolic process |
| regulation of adaptive immune response |
| response to corticosteroid |
| maintenance of location |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of protein kinase B signaling |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| glial cell differentiation |
| positive regulation of endopeptidase activity |
| cytokine activity |
| regulation of response to cytokine stimulus |
| regulation of phosphatase activity |
| regulation of insulin secretion |
| regulation of reactive oxygen species metabolic process |
| regulation of morphogenesis of an epithelium |
| negative regulation of protein transport |
| protein localization to plasma membrane |
| cellular response to lipopolysaccharide |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of JNK cascade |
| negative regulation of establishment of protein localization |
| regulation of lipid biosynthetic process |
| positive regulation of hemopoiesis |
| regulation of protein localization to membrane |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of ossification |
| cellular response to molecule of bacterial origin |
| positive regulation of peptidase activity |
| regulation of leukocyte migration |
| monosaccharide metabolic process |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| regulation of viral process |
| regulation of neuron apoptotic process |
| cellular response to acid chemical |
| regulation of peptide hormone secretion |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of dephosphorylation |
| cellular response to toxic substance |
| gliogenesis |
| negative regulation of multi-organism process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of protein catabolic process |
| transcription regulatory region DNA binding |
| regulation of synapse organization |
| positive regulation of immune effector process |
| myeloid cell differentiation |
| regulation of organelle assembly |
| regulation of protein kinase B signaling |
| regulation of symbiosis, encompassing mutualism through parasitism |
| membrane raft |
| regulation of myeloid cell differentiation |
| negative regulation of apoptotic signaling pathway |
| regulation of synapse structure or activity |
| protein localization to cell periphery |
| negative regulation of secretion |
| regulation of stress-activated MAPK cascade |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| cellular response to tumor necrosis factor |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of protein complex assembly |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| regulation of animal organ morphogenesis |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of MAP kinase activity |
| response to tumor necrosis factor |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| response to virus |
| apoptotic signaling pathway |
| positive regulation of peptide secretion |
| negative regulation of neurogenesis |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| cognition |
| negative regulation of mitotic cell cycle |
| negative regulation of catabolic process |
| regulation of neuron death |
| negative regulation of nervous system development |
| response to lipopolysaccharide |
| lipid localization |
| positive regulation of cellular protein localization |
| response to molecule of bacterial origin |
| response to steroid hormone |
| activation of protein kinase activity |
| defense response to bacterium |
| leukocyte differentiation |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| extracellular matrix organization |
| regulation of MAP kinase activity |
| response to acid chemical |
| humoral immune response |
| regulation of translation |
| regulation of neurotransmitter levels |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| MAPK cascade |
| leukocyte migration |
| regulation of protein catabolic process |
| extracellular structure organization |
| signal transduction by protein phosphorylation |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| positive regulation of secretion by cell |
| regulation of cellular amide metabolic process |
| positive regulation of cell adhesion |
| gland development |
| regulation of endopeptidase activity |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| embryonic organ development |
| positive regulation of secretion |
| modulation of chemical synaptic transmission |
| negative regulation of immune system process |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| carbohydrate metabolic process |
| protein localization to membrane |
| negative regulation of transport |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of cell migration |
| cell-cell adhesion |
| response to toxic substance |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cellular component biogenesis |
| cellular response to lipid |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| cell population proliferation |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| actin filament-based process |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| cell surface |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of neurogenesis |
| regulation of cellular catabolic process |
| tube development |
| regulation of cell migration |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| defense response to other organism |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| negative regulation of cell death |
| regulation of catabolic process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell activation |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10769
- Expression level (log2 read counts): -0.54
Expression Distribution
TNF Expression in NALM6 Cells: -0.54
