TNFRSF13B

Entrez Summary: The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. {ECO:0000269|PubMed:10956646, ECO:0000269|PubMed:10973284}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of B cell proliferation
B cell homeostasis
negative regulation of B cell activation
lymphocyte homeostasis
regulation of B cell proliferation
leukocyte homeostasis
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
negative regulation of leukocyte proliferation
hematopoietic progenitor cell differentiation
tumor necrosis factor-mediated signaling pathway
negative regulation of lymphocyte activation
negative regulation of leukocyte activation
negative regulation of cell activation
homeostasis of number of cells
signaling receptor activity
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
cellular response to tumor necrosis factor
response to tumor necrosis factor
negative regulation of immune system process
regulation of lymphocyte activation
hemopoiesis
regulation of leukocyte activation
hematopoietic or lymphoid organ development
adaptive immune response
regulation of cell activation
immune system development
cytokine-mediated signaling pathway
negative regulation of cell population proliferation
cellular response to cytokine stimulus
response to cytokine
integral component of plasma membrane
regulation of cell population proliferation
homeostatic process
regulation of immune system process
immune response