TNFRSF14 [The Human Chemical-Genetic Interaction Map Project]

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======= TNFRSF14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF14
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8764|8764]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92956|Q92956]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. {ECO:0000269|PubMed:8898196}. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of adaptive immune memory response|
|regulation of adaptive immune memory response|
|positive regulation of cytokine secretion involved in immune response|
|tumor necrosis factor-activated receptor activity|
|negative regulation of alpha-beta T cell proliferation|
|regulation of cytokine secretion involved in immune response|
|regulation of alpha-beta T cell proliferation|
|positive regulation of T cell migration|
|positive regulation of lymphocyte migration|
|negative regulation of alpha-beta T cell activation|
|cytokine binding|
|regulation of T cell migration|
|negative regulation of adaptive immune response|
|positive regulation of cytokine production involved in immune response|
|T cell costimulation|
|lymphocyte costimulation|
|negative regulation of T cell proliferation|
|regulation of lymphocyte migration|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|virus receptor activity|
|negative regulation of leukocyte proliferation|
|defense response to Gram-negative bacterium|
|regulation of cytokine production involved in immune response|
|regulation of alpha-beta T cell activation|
|defense response to Gram-positive bacterium|
|viral entry into host cell|
|positive regulation of production of molecular mediator of immune response|
|entry into host|
|entry into host cell|
|negative regulation of T cell activation|
|tumor necrosis factor-mediated signaling pathway|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of leukocyte migration|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of T cell proliferation|
|interaction with host|
|regulation of adaptive immune response|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|viral life cycle|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|cellular response to tumor necrosis factor|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|positive regulation of peptide secretion|
|ubiquitin protein ligase binding|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|defense response to bacterium|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|regulation of peptide secretion|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|defense response to other organism|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.93|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.81|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.76|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.72|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6830
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF14 Expression in NALM6 Cells: 2.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>