TNFRSF14

Gene Information

Official Symbol: TNFRSF14
Official Name: TNF receptor superfamily member 14
Aliases and Previous Symbols: N/A
Entrez ID: 8764
UniProt: Q92956
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. {ECO:0000269|PubMed:8898196}. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifurtimox 1μM R03 exp141	-1.93
Trichostatin-A 0.06μM R07 exp415	-1.81
Beta-Estradiol 0.55μM R07 exp425	-1.76
Fas-L 44ng/ml R08 exp482	1.72
UM131593 0.1μM R01 exp58	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6830
Expression level (log2 read counts): 2.61

Expression Distribution

negative regulation of adaptive immune memory response
regulation of adaptive immune memory response
positive regulation of cytokine secretion involved in immune response
tumor necrosis factor-activated receptor activity
negative regulation of alpha-beta T cell proliferation
regulation of cytokine secretion involved in immune response
regulation of alpha-beta T cell proliferation
positive regulation of T cell migration
positive regulation of lymphocyte migration
negative regulation of alpha-beta T cell activation
cytokine binding
regulation of T cell migration
negative regulation of adaptive immune response
positive regulation of cytokine production involved in immune response
T cell costimulation
lymphocyte costimulation
negative regulation of T cell proliferation
regulation of lymphocyte migration
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
virus receptor activity
negative regulation of leukocyte proliferation
defense response to Gram-negative bacterium
regulation of cytokine production involved in immune response
regulation of alpha-beta T cell activation
defense response to Gram-positive bacterium
viral entry into host cell
positive regulation of production of molecular mediator of immune response
entry into host
entry into host cell
negative regulation of T cell activation
tumor necrosis factor-mediated signaling pathway
negative regulation of leukocyte cell-cell adhesion
positive regulation of leukocyte migration
positive regulation of cytokine secretion
regulation of production of molecular mediator of immune response
negative regulation of lymphocyte activation
negative regulation of immune response
regulation of T cell proliferation
interaction with host