TNFRSF1B

Gene Information

Official Symbol: TNFRSF1B
Official Name: TNF receptor superfamily member 1B
Aliases and Previous Symbols: N/A
Entrez ID: 7133
UniProt: P20333
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7534
Expression level (log2 read counts): 3.67

Expression Distribution

glial cell-neuron signaling
tumor necrosis factor binding
tumor necrosis factor receptor superfamily complex
negative regulation of extracellular matrix constituent secretion
positive regulation of apoptotic process involved in development
positive regulation of apoptotic process involved in morphogenesis
regulation of extracellular matrix constituent secretion
varicosity
tumor necrosis factor-activated receptor activity
negative regulation of extracellular matrix organization
negative regulation of neuroinflammatory response
regulation of apoptotic process involved in development
regulation of apoptotic process involved in morphogenesis
positive regulation of membrane protein ectodomain proteolysis
regulation of cytokine secretion involved in immune response
positive regulation of myelination
pulmonary valve development
positive regulation of oligodendrocyte differentiation
regulation of membrane protein ectodomain proteolysis
negative regulation of cardiac muscle hypertrophy
negative regulation of muscle hypertrophy
regulation of neuroinflammatory response
regulation of T cell cytokine production
aortic valve development
RNA destabilization
semi-lunar valve development
regulation of extracellular matrix organization
regulation of oligodendrocyte differentiation
positive regulation of glial cell differentiation
regulation of myelination
regulation of cardiac muscle hypertrophy
regulation of muscle hypertrophy
heart valve development
positive regulation of nervous system process
regulation of glial cell differentiation
positive regulation of gliogenesis
regulation of T cell mediated immunity
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of cytokine production involved in immune response
regulation of muscle adaptation