TNFSF13

Gene Information

Official Symbol: TNFSF13
Official Name: TNF superfamily member 13
Aliases and Previous Symbols: N/A
Entrez ID: 8741
UniProt: O75888
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].
UniProt Summary: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {ECO:0000269|PubMed:10973284}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10042
Expression level (log2 read counts): 1.46

Expression Distribution

positive regulation of isotype switching to IgA isotypes
regulation of isotype switching to IgA isotypes
positive regulation of isotype switching
tumor necrosis factor receptor binding
regulation of isotype switching
positive regulation of B cell mediated immunity
positive regulation of immunoglobulin mediated immune response
positive regulation of DNA recombination
positive regulation of immunoglobulin production
regulation of immunoglobulin mediated immune response
regulation of B cell mediated immunity
regulation of immunoglobulin production
positive regulation of production of molecular mediator of immune response
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of DNA recombination
positive regulation of lymphocyte mediated immunity
positive regulation of adaptive immune response
tumor necrosis factor-mediated signaling pathway
positive regulation of leukocyte mediated immunity
regulation of production of molecular mediator of immune response
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of adaptive immune response
positive regulation of B cell activation
cytokine activity
regulation of mRNA stability
regulation of RNA stability
positive regulation of DNA metabolic process
regulation of mRNA catabolic process
regulation of leukocyte mediated immunity
regulation of B cell activation
positive regulation of immune effector process
cellular response to tumor necrosis factor
response to tumor necrosis factor
regulation of mRNA metabolic process
signaling receptor binding
regulation of DNA metabolic process
positive regulation of lymphocyte activation
positive regulation of leukocyte activation
positive regulation of cell activation