TNFSF14 [The Human Chemical-Genetic Interaction Map Project]

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======= TNFSF14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFSF14
  * **<color #00a2e8>Official Name</color>**: TNF superfamily member 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8740|8740]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43557|O43557]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFSF14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFSF14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|positive regulation of myoblast fusion|
|regulation of myoblast fusion|
|positive regulation of lymphocyte chemotaxis|
|positive regulation of myoblast differentiation|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|regulation of lymphocyte chemotaxis|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|tumor necrosis factor receptor binding|
|positive regulation of T cell migration|
|positive regulation of myotube differentiation|
|T cell homeostasis|
|positive regulation of lymphocyte migration|
|T cell proliferation|
|regulation of T cell migration|
|regulation of myoblast differentiation|
|lymphocyte homeostasis|
|T cell costimulation|
|lymphocyte costimulation|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|regulation of lymphocyte migration|
|leukocyte homeostasis|
|positive regulation of NIK/NF-kappaB signaling|
|cellular response to mechanical stimulus|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|positive regulation of muscle cell differentiation|
|positive regulation of leukocyte chemotaxis|
|negative regulation of cysteine-type endopeptidase activity|
|leukocyte proliferation|
|regulation of striated muscle cell differentiation|
|regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte chemotaxis|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of muscle cell differentiation|
|cytokine activity|
|regulation of leukocyte migration|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|response to mechanical stimulus|
|regulation of chemotaxis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|T cell activation|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|regulation of leukocyte cell-cell adhesion|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of T cell activation|
|cellular response to external stimulus|
|signaling receptor binding|
|negative regulation of proteolysis|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|apoptotic process|
|leukocyte activation|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFSF14 Expression in NALM6 Cells: 1.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>