TNFSF14
Gene Information
- Official Symbol: TNFSF14
- Official Name: TNF superfamily member 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 8740
- UniProt: O43557
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Pfam Domains GO Terms
Pfam Domains
| TNF |
GO Terms
| positive regulation of T cell chemotaxis |
| regulation of T cell chemotaxis |
| positive regulation of myoblast fusion |
| regulation of myoblast fusion |
| positive regulation of lymphocyte chemotaxis |
| positive regulation of myoblast differentiation |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| regulation of lymphocyte chemotaxis |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| tumor necrosis factor receptor binding |
| positive regulation of T cell migration |
| positive regulation of myotube differentiation |
| T cell homeostasis |
| positive regulation of lymphocyte migration |
| T cell proliferation |
| regulation of T cell migration |
| regulation of myoblast differentiation |
| lymphocyte homeostasis |
| T cell costimulation |
| lymphocyte costimulation |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| regulation of lymphocyte migration |
| leukocyte homeostasis |
| positive regulation of NIK/NF-kappaB signaling |
| cellular response to mechanical stimulus |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| positive regulation of muscle cell differentiation |
| positive regulation of leukocyte chemotaxis |
| negative regulation of cysteine-type endopeptidase activity |
| leukocyte proliferation |
| regulation of striated muscle cell differentiation |
| regulation of NIK/NF-kappaB signaling |
| regulation of leukocyte chemotaxis |
| tumor necrosis factor-mediated signaling pathway |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| regulation of muscle cell differentiation |
| cytokine activity |
| regulation of leukocyte migration |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| response to mechanical stimulus |
| regulation of chemotaxis |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| T cell activation |
| cellular response to tumor necrosis factor |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| positive regulation of cell-cell adhesion |
| response to tumor necrosis factor |
| regulation of leukocyte cell-cell adhesion |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of T cell activation |
| cellular response to external stimulus |
| signaling receptor binding |
| negative regulation of proteolysis |
| positive regulation of lymphocyte activation |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| cell population proliferation |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| apoptotic process |
| leukocyte activation |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| cell activation |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| positive regulation of developmental process |
| regulation of apoptotic process |
| regulation of programmed cell death |
| extracellular space |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8344
- Expression level (log2 read counts): 1.96
Expression Distribution
TNFSF14 Expression in NALM6 Cells: 1.96
