TNFSF18

Gene Information

Official Symbol: TNFSF18
Official Name: TNF superfamily member 18
Aliases and Previous Symbols: N/A
Entrez ID: 8995
UniProt: Q9UNG2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17324
Expression level (log2 read counts): -4.6

Expression Distribution

T cell proliferation involved in immune response
tumor necrosis factor receptor superfamily binding
T cell proliferation
T cell activation involved in immune response
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
lymphocyte proliferation
positive regulation of receptor signaling pathway via JAK-STAT
mononuclear cell proliferation
positive regulation of receptor signaling pathway via STAT
leukocyte proliferation
lymphocyte activation involved in immune response
tumor necrosis factor-mediated signaling pathway
positive regulation of leukocyte migration
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
positive regulation of NF-kappaB transcription factor activity
regulation of T cell proliferation
cytokine activity
positive regulation of peptidyl-tyrosine phosphorylation
regulation of leukocyte migration
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
T cell activation
cellular response to tumor necrosis factor
regulation of peptidyl-tyrosine phosphorylation
positive regulation of DNA-binding transcription factor activity
response to tumor necrosis factor
regulation of T cell activation
signaling receptor binding
lymphocyte activation
positive regulation of cell adhesion
regulation of DNA-binding transcription factor activity
positive regulation of cell migration
regulation of lymphocyte activation
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
cell population proliferation