TNIP2

Gene Information

Official Symbol: TNIP2
Official Name: TNFAIP3 interacting protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 79155
UniProt: Q8NFZ5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6831
Expression level (log2 read counts): 4.73

Expression Distribution

CD40 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 9 signaling pathway
K63-linked polyubiquitin modification-dependent protein binding
positive regulation of macrophage activation
polyubiquitin modification-dependent protein binding
negative regulation of endothelial cell apoptotic process
negative regulation of epithelial cell apoptotic process
regulation of endothelial cell apoptotic process
regulation of macrophage activation
I-kappaB kinase/NF-kappaB signaling
regulation of epithelial cell apoptotic process
interleukin-1-mediated signaling pathway
toll-like receptor signaling pathway
stress-activated MAPK cascade
pattern recognition receptor signaling pathway
stress-activated protein kinase signaling cascade
positive regulation of B cell activation
cellular response to interleukin-1
protein stabilization
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
response to interleukin-1
regulation of B cell activation
cellular response to biotic stimulus
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
activation of innate immune response
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
response to lipopolysaccharide
response to molecule of bacterial origin
positive regulation of innate immune response
positive regulation of lymphocyte activation
positive regulation of response to biotic stimulus
MAPK cascade
signal transduction by protein phosphorylation