TNIP3

Gene Information

Official Symbol: TNIP3
Official Name: TNFAIP3 interacting protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 79931
UniProt: Q96KP6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. {ECO:0000269|PubMed:17088249}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13287
Expression level (log2 read counts): 1.18

Expression Distribution

toll-like receptor 4 signaling pathway
polyubiquitin modification-dependent protein binding
MyD88-independent toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
toll-like receptor signaling pathway
pattern recognition receptor signaling pathway
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
activation of innate immune response
protein deubiquitination
protein modification by small protein removal
response to lipopolysaccharide
response to molecule of bacterial origin
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of innate immune response
positive regulation of defense response
inflammatory response
negative regulation of intracellular signal transduction
positive regulation of multi-organism process
cellular response to lipid
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
response to bacterium
regulation of defense response
regulation of multi-organism process
response to lipid
positive regulation of immune response
protein modification by small protein conjugation or removal
cellular response to oxygen-containing compound
regulation of response to external stimulus
positive regulation of immune system process
regulation of immune response
positive regulation of transcription by RNA polymerase II