TNNC1

Entrez Summary: Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008].
UniProt Summary: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 10μM R00 exp30	-1.96
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.74
GSK-J4 1μM R07 exp362	1.83
Ammonium tetrathiomolybdate 10μM R08 exp448	1.88
Ibrutinib 1μM R07 exp372	2.07
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.09

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of muscle filament sliding speed
diaphragm contraction
involuntary skeletal muscle contraction
cardiac Troponin complex
regulation of muscle filament sliding
troponin T binding
troponin I binding
transition between fast and slow fiber
troponin complex
respiratory system process
regulation of skeletal muscle adaptation
skeletal muscle contraction
muscle filament sliding
actin-myosin filament sliding
respiratory gaseous exchange by respiratory system
regulation of actin filament-based movement
musculoskeletal movement
multicellular organismal movement
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue development
calcium-dependent protein binding
cardiac muscle tissue morphogenesis
cardiac ventricle morphogenesis
cardiac muscle contraction
muscle tissue morphogenesis
regulation of ATPase activity
regulation of muscle adaptation
muscle organ morphogenesis
heart contraction
actin-mediated cell contraction
heart process
striated muscle contraction
actin filament-based movement
cardiac chamber morphogenesis
cardiac ventricle development
regulation of muscle contraction
cardiac muscle tissue development
cardiac chamber development
actin filament binding
regulation of muscle system process