TNRC6B

Gene Information

Official Symbol: TNRC6B
Official Name: trinucleotide repeat containing adaptor 6B
Aliases and Previous Symbols: N/A
Entrez ID: 23112
UniProt: Q9UPQ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3419
Expression level (log2 read counts): 6.8

Expression Distribution

Screen	Score
Rapamycin 1μM R00 exp29	1.74
Cadmium 60μM R08 exp462	1.79

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of translation, ncRNA-mediated
negative regulation of translation, ncRNA-mediated
miRNA mediated inhibition of translation
regulation of nuclear-transcribed mRNA poly(A) tail shortening
RISC complex
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Wnt signaling pathway, calcium modulating pathway
gene silencing by miRNA
positive regulation of mRNA catabolic process
regulation of megakaryocyte differentiation
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
positive regulation of mRNA metabolic process
P-body
gene silencing by RNA
negative regulation of translation
non-canonical Wnt signaling pathway
negative regulation of cellular amide metabolic process
gene silencing
regulation of mRNA catabolic process
regulation of myeloid cell differentiation
regulation of gene expression, epigenetic
regulation of mRNA metabolic process
regulation of translation
Wnt signaling pathway
cell-cell signaling by wnt
positive regulation of cellular catabolic process
regulation of cellular amide metabolic process
cell surface receptor signaling pathway involved in cell-cell signaling
positive regulation of catabolic process
regulation of hemopoiesis
posttranscriptional regulation of gene expression
regulation of cellular catabolic process
regulation of catabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
cell-cell signaling
negative regulation of cellular macromolecule biosynthetic process