TOE1 [The Human Chemical-Genetic Interaction Map Project]

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======= TOE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOE1
  * **<color #00a2e8>Official Name</color>**: target of EGR1, exonuclease
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114034|114034]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GM8|Q96GM8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613931|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAF1|
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA binding|
|poly(A)-specific ribonuclease activity|
|snRNA 3-end processing|
|3-5-exoribonuclease activity|
|snRNA processing|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|snRNA metabolic process|
|ncRNA 3-end processing|
|Cajal body|
|RNA 3-end processing|
|RNA phosphodiester bond hydrolysis|
|nuclear body|
|nucleic acid phosphodiester bond hydrolysis|
|ncRNA processing|
|nuclear speck|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-1.83|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.74|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.72|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.7|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.7|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.73|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.75|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.89|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.9|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.07|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.445|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 166/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|6/28|
|blood|7/28|
|bone|6/26|
|breast|3/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|5/20|
|lung|17/75|
|lymphocyte|1/16|
|ovary|11/26|
|pancreas|7/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|11/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1606
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOE1 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>