TOE1

Entrez Summary: N/A
UniProt Summary: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
B02 10μM R08 exp453	-1.83
CFI-400945 25μM R08 exp469	-1.74
5-Fluorouracil 2μM R00 exp1	-1.72
GSK-J4 1μM R07 exp362	-1.7
Senexin-A 25μM R07 exp400	1.7
Doxycycline 10μM R00 exp18	1.73
Dimethyloxaloylglycine 11μM R07 exp314	1.75
UM0129480 7μM R02 exp85	1.89
Ethanol 0.01 R05 exp234	1.9
Ammonium tetrathiomolybdate 10μM R08 exp448	2.07
I-BRD9 4μM R07 exp365	2.47

Global Fraction of Cell Lines Where Essential: 166/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	6/28
blood	7/28
bone	6/26
breast	3/33
central nervous system	15/56
cervix	0/4
colorectal	5/17
esophagus	4/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	5/20
lung	17/75
lymphocyte	1/16
ovary	11/26
pancreas	7/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	11/29
uterus	3/5

Expression Distribution

CAF1
zf-CCCH

snRNA binding
poly(A)-specific ribonuclease activity
snRNA 3-end processing
3-5-exoribonuclease activity
snRNA processing
RNA phosphodiester bond hydrolysis, exonucleolytic
snRNA metabolic process
ncRNA 3-end processing
Cajal body
RNA 3-end processing
RNA phosphodiester bond hydrolysis
nuclear body
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
nuclear speck
ncRNA metabolic process
nucleolus
RNA processing
RNA metabolic process
gene expression