TOLLIP

Entrez Summary: N/A
UniProt Summary: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). {ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:25042851}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CUE
C2

interleukin-1 receptor complex
interleukin-1, type I receptor binding
interleukin-18 receptor complex
Toll-like receptor binding
positive regulation of protein sumoylation
SUMO binding
protein localization to endosome
regulation of protein sumoylation
ubiquitin conjugating enzyme binding
specific granule lumen
ubiquitin binding
azurophil granule lumen
kinase binding
interleukin-1-mediated signaling pathway
positive regulation of protein modification by small protein conjugation or removal
cellular response to interleukin-1
response to interleukin-1
regulation of protein modification by small protein conjugation or removal
autophagy
process utilizing autophagic mechanism
nuclear body
ubiquitin protein ligase binding
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
inflammatory response
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
myeloid leukocyte activation
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
leukocyte activation involved in immune response
cell activation involved in immune response
cytokine-mediated signaling pathway