TOP1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TOP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOP1
  * **<color #00a2e8>Official Name</color>**: DNA topoisomerase I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7150|7150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11387|P11387]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Topoisom I|
|Topoisom I N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA topoisomerase complex (ATP-hydrolyzing)|
|DNA topoisomerase type I activity|
|supercoiled DNA binding|
|embryonic cleavage|
|replication fork protection complex|
|DNA topological change|
|nuclear chromosome|
|protein-DNA complex|
|circadian regulation of gene expression|
|P-body|
|double-stranded DNA binding|
|single-stranded DNA binding|
|fibrillar center|
|perikaryon|
|circadian rhythm|
|chromatin remodeling|
|peptidyl-serine phosphorylation|
|peptidyl-serine modification|
|DNA replication|
|protein domain specific binding|
|chromosome segregation|
|rhythmic process|
|DNA conformation change|
|protein serine/threonine kinase activity|
|chromatin binding|
|cell division|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|chromatin organization|
|viral process|
|DNA metabolic process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|peptidyl-amino acid modification|
|protein phosphorylation|
|embryo development|
|response to drug|
|programmed cell death|
|chromosome organization|
|cell death|
|phosphorylation|
|RNA binding|
|DNA binding|
|ATP binding|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.84|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.68|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.32|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.22|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.17|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.11|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.08|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.06|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.01|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.99|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.96|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.86|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.85|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.8|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.78|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.81|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.86|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.14|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.18|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.63|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 135/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|4/28|
|bone|3/25|
|breast|8/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|3/15|
|kidney|8/21|
|liver|2/20|
|lung|13/75|
|lymphocyte|3/14|
|ovary|6/26|
|pancreas|1/24|
|peripheral nervous system|3/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1406
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOP1 Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>