TOP1

• Official Symbol: TOP1
• Official Name: DNA topoisomerase I
• Aliases and Previous Symbols: N/A
• Entrez ID: 7150
• UniProt: P11387
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
• UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 1406
• Expression level (log2 read counts): 8.51

Expression Distribution

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TOP1 Expression in NALM6 Cells: 8.51