TOR1B [The Human Chemical-Genetic Interaction Map Project]

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======= TOR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOR1B
  * **<color #00a2e8>Official Name</color>**: torsin family 1 member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27348|27348]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14657|O14657]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Torsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear membrane organization|
|chaperone cofactor-dependent protein refolding|
|de novo posttranslational protein folding|
|de novo protein folding|
|nuclear envelope organization|
|endoplasmic reticulum organization|
|chaperone-mediated protein folding|
|nucleus organization|
|response to unfolded protein|
|nuclear envelope|
|response to topologically incorrect protein|
|protein folding|
|ATPase activity|
|nuclear membrane|
|endoplasmic reticulum lumen|
|protein homooligomerization|
|endomembrane system organization|
|protein complex oligomerization|
|membrane organization|
|endoplasmic reticulum|
|ATP binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.01|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.96|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.81|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.8|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.7|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.81|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOR1B Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>