TOR1B

Entrez Summary: N/A
UniProt Summary: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nuclear membrane organization
chaperone cofactor-dependent protein refolding
de novo posttranslational protein folding
de novo protein folding
nuclear envelope organization
endoplasmic reticulum organization
chaperone-mediated protein folding
nucleus organization
response to unfolded protein
nuclear envelope
response to topologically incorrect protein
protein folding
ATPase activity
nuclear membrane
endoplasmic reticulum lumen
protein homooligomerization
endomembrane system organization
protein complex oligomerization
membrane organization
endoplasmic reticulum
ATP binding
protein-containing complex assembly
protein-containing complex subunit organization