TP53BP2

Gene Information

Official Symbol: TP53BP2
Official Name: tumor protein p53 binding protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 7159
UniProt: Q13625
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16630
Expression level (log2 read counts): 6.49

Expression Distribution

Screen	Score
Bleomycin 5μM R08 exp459	-2.07
Temozolomide 200μM R04 exp189	2.22

SH3 2
SH3 1
Ank 2
Ank

positive regulation of execution phase of apoptosis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
NF-kappaB binding
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of execution phase of apoptosis
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
SH3/SH2 adaptor activity
positive regulation of establishment of protein localization to mitochondrion
p53 binding
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
positive regulation of neuron death
positive regulation of mitochondrion organization
signal transduction by p53 class mediator
positive regulation of protein localization to membrane
mitochondrial membrane organization
SH3 domain binding
intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
regulation of mitochondrion organization
regulation of protein localization to membrane
mitochondrial transport
apoptotic signaling pathway
regulation of neuron death
positive regulation of cellular protein localization
regulation of apoptotic signaling pathway
mitochondrion organization
positive regulation of establishment of protein localization
regulation of cellular protein localization
cell junction
negative regulation of cell cycle
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
perinuclear region of cytoplasm
positive regulation of cell death