TP53TG3D [The Human Chemical-Genetic Interaction Map Project]

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======= TP53TG3D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP53TG3D
  * **<color #00a2e8>Official Name</color>**: TP53 target 3D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=729264|729264]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULZ0|Q9ULZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP53TG3D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP53TG3D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a significant role in p53/TP53-mediating signaling pathway. {ECO:0000269|PubMed:10534768}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.97|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.81|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.7|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.71|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.79|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.83|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.05|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.53|
|[[:human genes:p:psmb4|PSMB4]]|0.51|
|[[:human genes:c:chd4|CHD4]]|0.506|
|[[:human genes:m:mfsd12|MFSD12]]|0.482|
|[[:human genes:p:psmd3|PSMD3]]|0.481|
|[[:human genes:e:exosc9|EXOSC9]]|0.468|
|[[:human genes:c:cactin|CACTIN]]|0.467|
|[[:human genes:c:cdh24|CDH24]]|0.464|
|[[:human genes:t:tceb3c|TCEB3C]]|0.463|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.46|
|[[:human genes:r:rrp15|RRP15]]|0.458|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.458|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.458|
|[[:human genes:s:supt5h|SUPT5H]]|0.455|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.451|
|[[:human genes:c:col2a1|COL2A1]]|0.448|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.448|
|[[:human genes:r:rpl6|RPL6]]|0.448|
|[[:human genes:s:slc4a1|SLC4A1]]|0.447|
|[[:human genes:i:ik|IK]]|0.446|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:c:cln6|CLN6]]|0.445|
|[[:human genes:a:aqr|AQR]]|0.445|
|[[:human genes:s:slc6a17|SLC6A17]]|0.444|
|[[:human genes:p:psmb2|PSMB2]]|0.444|
|[[:human genes:d:ddtl|DDTL]]|0.444|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.444|
|[[:human genes:c:copg1|COPG1]]|0.444|
|[[:human genes:c:cbwd3|CBWD3]]|0.443|
|[[:human genes:n:narfl|NARFL]]|0.438|
|[[:human genes:c:cep192|CEP192]]|0.437|
|[[:human genes:r:rps7|RPS7]]|0.437|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.436|
|[[:human genes:p:polr2d|POLR2D]]|0.435|
|[[:human genes:a:aamp|AAMP]]|0.434|
|[[:human genes:r:rrp7a|RRP7A]]|0.432|
|[[:human genes:a:aatf|AATF]]|0.432|
|[[:human genes:u:utp3|UTP3]]|0.431|
|[[:human genes:o:ogfr|OGFR]]|0.431|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:s:snrpa1|SNRPA1]]|0.43|
|[[:human genes:r:rps19|RPS19]]|0.43|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.429|
|[[:human genes:v:vps28|VPS28]]|0.428|
|[[:human genes:l:lrr1|LRR1]]|0.427|
|[[:human genes:m:mt1e|MT1E]]|0.427|
|[[:human genes:r:rpl35|RPL35]]|0.425|
|[[:human genes:e:eif4a3|EIF4A3]]|0.424|
|[[:human genes:r:rnf113a|RNF113A]]|0.424|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.424|
|[[:human genes:s:sap30bp|SAP30BP]]|0.423|
|[[:human genes:l:lad1|LAD1]]|0.421|
|[[:human genes:n:nol9|NOL9]]|0.421|
|[[:human genes:k:kctd17|KCTD17]]|0.421|
|[[:human genes:n:nupl1|NUPL1]]|0.421|
|[[:human genes:c:ctage4|CTAGE4]]|0.42|
|[[:human genes:c:ccdc116|CCDC116]]|0.42|
|[[:human genes:p:pan3|PAN3]]|0.42|
|[[:human genes:c:cdca3|CDCA3]]|0.42|
|[[:human genes:p:psma6|PSMA6]]|0.42|
|[[:human genes:p:pwp2|PWP2]]|0.416|
|[[:human genes:r:ranbp2|RANBP2]]|0.415|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.415|
|[[:human genes:c:cbwd6|CBWD6]]|0.415|
|[[:human genes:s:sult1a4|SULT1A4]]|0.414|
|[[:human genes:s:sult1a3|SULT1A3]]|0.414|
|[[:human genes:p:psmd2|PSMD2]]|0.412|
|[[:human genes:p:pole|POLE]]|0.409|
|[[:human genes:n:ncapg|NCAPG]]|0.408|
|[[:human genes:h:hap1|HAP1]]|0.408|
|[[:human genes:c:cbwd5|CBWD5]]|0.405|
|[[:human genes:p:polr2l|POLR2L]]|0.404|
|[[:human genes:r:rbbp5|RBBP5]]|0.403|
|[[:human genes:s:slc38a7|SLC38A7]]|0.403|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.403|
|[[:human genes:p:pbxip1|PBXIP1]]|0.403|
|[[:human genes:f:fam160a1|FAM160A1]]|0.402|
|[[:human genes:o:orc6|ORC6]]|0.402|
|[[:human genes:c:chmp4b|CHMP4B]]|0.4|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2011
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP53TG3D Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>