TPH1 [The Human Chemical-Genetic Interaction Map Project]

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======= TPH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPH1
  * **<color #00a2e8>Official Name</color>**: tryptophan hydroxylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7166|7166]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17752|P17752]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Biopterin H|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tryptophan 5-monooxygenase activity|
|serotonin biosynthetic process|
|indole-containing compound biosynthetic process|
|indolalkylamine biosynthetic process|
|primary amino compound biosynthetic process|
|serotonin metabolic process|
|primary amino compound metabolic process|
|indolalkylamine metabolic process|
|mammary gland alveolus development|
|mammary gland lobule development|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|indole-containing compound metabolic process|
|response to immobilization stress|
|phenol-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|neurotransmitter biosynthetic process|
|bone remodeling|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|positive regulation of fat cell differentiation|
|amine metabolic process|
|negative regulation of ossification|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|tissue remodeling|
|regulation of fat cell differentiation|
|mammary gland development|
|iron ion binding|
|circadian rhythm|
|organic hydroxy compound biosynthetic process|
|regulation of ossification|
|ammonium ion metabolic process|
|rhythmic process|
|cellular amino acid metabolic process|
|neuron projection|
|regulation of neurotransmitter levels|
|gland development|
|organic hydroxy compound metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|oxoacid metabolic process|
|organic acid metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPH1 Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>