TPH1

Entrez Summary: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tryptophan 5-monooxygenase activity
serotonin biosynthetic process
indole-containing compound biosynthetic process
indolalkylamine biosynthetic process
primary amino compound biosynthetic process
serotonin metabolic process
primary amino compound metabolic process
indolalkylamine metabolic process
mammary gland alveolus development
mammary gland lobule development
cellular biogenic amine biosynthetic process
amine biosynthetic process
indole-containing compound metabolic process
response to immobilization stress
phenol-containing compound biosynthetic process
aromatic amino acid family metabolic process
neurotransmitter biosynthetic process
bone remodeling
cellular biogenic amine metabolic process
cellular amine metabolic process
positive regulation of fat cell differentiation
amine metabolic process
negative regulation of ossification
phenol-containing compound metabolic process
neurotransmitter metabolic process
tissue remodeling
regulation of fat cell differentiation
mammary gland development
iron ion binding
circadian rhythm
organic hydroxy compound biosynthetic process
regulation of ossification
ammonium ion metabolic process
rhythmic process
cellular amino acid metabolic process
neuron projection
regulation of neurotransmitter levels
gland development
organic hydroxy compound metabolic process
carboxylic acid metabolic process