TPH2

Entrez Summary: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.73
MS094 2μM R03 exp136	1.7
Rotenone 2μM R00 exp33	1.7
CCCP 0.1μM R00 exp10	1.83
Cannabidiol 20μM R08 exp466	1.91

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tryptophan 5-monooxygenase activity
serotonin biosynthetic process
indolalkylamine biosynthetic process
primary amino compound biosynthetic process
indole-containing compound biosynthetic process
serotonin metabolic process
primary amino compound metabolic process
cellular response to lithium ion
indolalkylamine metabolic process
response to lithium ion
cellular biogenic amine biosynthetic process
indole-containing compound metabolic process
amine biosynthetic process
phenol-containing compound biosynthetic process
aromatic amino acid family metabolic process
neurotransmitter biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
response to activity
amine metabolic process
response to estrogen
phenol-containing compound metabolic process
neurotransmitter metabolic process
iron ion binding
circadian rhythm
response to glucocorticoid
response to calcium ion
response to corticosteroid
organic hydroxy compound biosynthetic process
cellular response to metal ion
ammonium ion metabolic process
cellular response to inorganic substance
rhythmic process
cellular amino acid metabolic process
neuron projection
response to steroid hormone
regulation of neurotransmitter levels
response to metal ion
organic hydroxy compound metabolic process
response to nutrient levels