TPK1 [The Human Chemical-Genetic Interaction Map Project]

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======= TPK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPK1
  * **<color #00a2e8>Official Name</color>**: thiamin pyrophosphokinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27010|27010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3S4|Q9H3S4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. {ECO:0000269|PubMed:11342111}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPK catalytic|
|TPK B1 binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thiamine binding|
|thiamine diphosphokinase activity|
|thiamine diphosphate biosynthetic process|
|thiamine diphosphate metabolic process|
|thiamine metabolic process|
|thiamine-containing compound metabolic process|
|pyrimidine-containing compound biosynthetic process|
|kinase activity|
|water-soluble vitamin metabolic process|
|pyrimidine-containing compound metabolic process|
|vitamin metabolic process|
|coenzyme biosynthetic process|
|sulfur compound biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|sulfur compound metabolic process|
|cofactor metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|organophosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.84|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.43|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.83|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.77|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.75|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.73|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.8|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.87|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.95|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.96|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.12|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.21|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.23|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.35|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.36|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.37|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.44|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc25a19|SLC25A19]]|0.694|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.629|
|[[:human genes:s:slc25a26|SLC25A26]]|0.575|
|[[:human genes:t:thg1l|THG1L]]|0.543|
|[[:human genes:f:fh|FH]]|0.538|
|[[:human genes:r:rft1|RFT1]]|0.531|
|[[:human genes:a:atxn10|ATXN10]]|0.514|
|[[:human genes:c:c17orf89|C17orf89]]|0.514|
|[[:human genes:p:ppcs|PPCS]]|0.512|
|[[:human genes:a:atic|ATIC]]|0.509|
|[[:human genes:r:rpia|RPIA]]|0.508|
|[[:human genes:r:rfk|RFK]]|0.507|
|[[:human genes:i:iba57|IBA57]]|0.505|
|[[:human genes:l:lipt2|LIPT2]]|0.503|
|[[:human genes:y:yars2|YARS2]]|0.5|
|[[:human genes:t:trmt61a|TRMT61A]]|0.493|
|[[:human genes:m:mrps5|MRPS5]]|0.491|
|[[:human genes:a:adsl|ADSL]]|0.49|
|[[:human genes:s:sars2|SARS2]]|0.49|
|[[:human genes:l:lsm10|LSM10]]|0.489|
|[[:human genes:s:srp14|SRP14]]|0.486|
|[[:human genes:c:cox5a|COX5A]]|0.481|
|[[:human genes:m:mipep|MIPEP]]|0.481|
|[[:human genes:m:mrpl23|MRPL23]]|0.479|
|[[:human genes:b:bcs1l|BCS1L]]|0.478|
|[[:human genes:n:nfu1|NFU1]]|0.474|
|[[:human genes:c:cox16|COX16]]|0.473|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.473|
|[[:human genes:t:tmem126b|TMEM126B]]|0.472|
|[[:human genes:a:alg1|ALG1]]|0.47|
|[[:human genes:m:mrpl21|MRPL21]]|0.47|
|[[:human genes:g:gemin8|GEMIN8]]|0.47|
|[[:human genes:p:pmm2|PMM2]]|0.467|
|[[:human genes:g:gemin7|GEMIN7]]|0.466|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.466|
|[[:human genes:p:pgm3|PGM3]]|0.465|
|[[:human genes:d:dpagt1|DPAGT1]]|0.464|
|[[:human genes:g:glrx5|GLRX5]]|0.462|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.462|
|[[:human genes:c:c15orf41|C15orf41]]|0.461|
|[[:human genes:m:mrps18a|MRPS18A]]|0.46|
|[[:human genes:n:ndufa3|NDUFA3]]|0.459|
|[[:human genes:s:srd5a3|SRD5A3]]|0.459|
|[[:human genes:n:ndufb11|NDUFB11]]|0.458|
|[[:human genes:r:rpusd4|RPUSD4]]|0.456|
|[[:human genes:d:dnlz|DNLZ]]|0.455|
|[[:human genes:p:pdss1|PDSS1]]|0.453|
|[[:human genes:a:alg6|ALG6]]|0.453|
|[[:human genes:m:mrps6|MRPS6]]|0.452|
|[[:human genes:t:tars2|TARS2]]|0.452|
|[[:human genes:m:mrps34|MRPS34]]|0.451|
|[[:human genes:r:rpp21|RPP21]]|0.451|
|[[:human genes:c:cep57|CEP57]]|0.45|
|[[:human genes:c:chchd4|CHCHD4]]|0.45|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.449|
|[[:human genes:m:mrps2|MRPS2]]|0.447|
|[[:human genes:d:dr1|DR1]]|0.446|
|[[:human genes:m:mrps16|MRPS16]]|0.446|
|[[:human genes:d:dhrsx|DHRSX]]|0.446|
|[[:human genes:s:sco2|SCO2]]|0.445|
|[[:human genes:m:mrps9|MRPS9]]|0.443|
|[[:human genes:g:gatc|GATC]]|0.442|
|[[:human genes:t:ten1|TEN1]]|0.442|
|[[:human genes:p:ppp6c|PPP6C]]|0.44|
|[[:human genes:t:tmem242|TMEM242]]|0.44|
|[[:human genes:m:mrps33|MRPS33]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.437|
|[[:human genes:t:trmt10a|TRMT10A]]|0.437|
|[[:human genes:d:dap3|DAP3]]|0.435|
|[[:human genes:r:rbfa|RBFA]]|0.435|
|[[:human genes:v:vezt|VEZT]]|0.435|
|[[:human genes:c:c12orf65|C12orf65]]|0.435|
|[[:human genes:t:ttc4|TTC4]]|0.434|
|[[:human genes:s:selrc1|SELRC1]]|0.434|
|[[:human genes:p:pars2|PARS2]]|0.433|
|[[:human genes:z:zcrb1|ZCRB1]]|0.429|
|[[:human genes:m:mrpl15|MRPL15]]|0.428|
|[[:human genes:e:eef1e1|EEF1E1]]|0.428|
|[[:human genes:d:dld|DLD]]|0.428|
|[[:human genes:s:ssb|SSB]]|0.427|
|[[:human genes:e:elac2|ELAC2]]|0.426|
|[[:human genes:m:mbtps2|MBTPS2]]|0.425|
|[[:human genes:p:ppcdc|PPCDC]]|0.425|
|[[:human genes:d:dars2|DARS2]]|0.424|
|[[:human genes:m:mrpl27|MRPL27]]|0.424|
|[[:human genes:u:uhrf1|UHRF1]]|0.424|
|[[:human genes:m:med16|MED16]]|0.423|
|[[:human genes:n:ndufb5|NDUFB5]]|0.423|
|[[:human genes:n:ndufb6|NDUFB6]]|0.422|
|[[:human genes:t:txnl4b|TXNL4B]]|0.419|
|[[:human genes:t:triap1|TRIAP1]]|0.417|
|[[:human genes:s:sucla2|SUCLA2]]|0.415|
|[[:human genes:m:mcat|MCAT]]|0.415|
|[[:human genes:t:tomm20|TOMM20]]|0.414|
|[[:human genes:c:cox6c|COX6C]]|0.412|
|[[:human genes:m:mrps14|MRPS14]]|0.412|
|[[:human genes:v:vars2|VARS2]]|0.412|
|[[:human genes:t:timm10|TIMM10]]|0.412|
|[[:human genes:u:urm1|URM1]]|0.411|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.411|
|[[:human genes:h:hars2|HARS2]]|0.41|
|[[:human genes:p:polg|POLG]]|0.41|
|[[:human genes:g:gfm2|GFM2]]|0.408|
|[[:human genes:p:polr3c|POLR3C]]|0.406|
|[[:human genes:z:zrsr2|ZRSR2]]|0.406|
|[[:human genes:r:rtcb|RTCB]]|0.404|
|[[:human genes:i:isca2|ISCA2]]|0.404|
|[[:human genes:g:gemin6|GEMIN6]]|0.403|
|[[:human genes:f:fars2|FARS2]]|0.4|
|[[:human genes:u:uap1|UAP1]]|0.4|
|[[:human genes:p:pmvk|PMVK]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 870
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPK1 Expression in NALM6 Cells: 2.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>