TPK1

Entrez Summary: This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. {ECO:0000269|PubMed:11342111}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCT251545 0.2μM R06 exp271	-2.84
GSK343 3μM R03 exp124	-2.43
UMK57 0.6μM R03 exp107	-1.83
Cincreasin 100μM R08 exp473	-1.77
UNC1999 2μM R03 exp155	-1.75
Palbociclib 1μM R07 exp382	1.73
Atovaquone 15μM R08 exp451	1.76
LLY-283 2.6μM R06 exp290	1.8
Ammonium tetrathiomolybdate 10μM R08 exp448	1.87
Hinokiflavone 12μM R08 exp487	1.95
PU-H71 1μM R08 exp515	1.96
Vitamin-D3 40μM R08 exp536	2.12
Cannabidiol 20μM R08 exp466	2.21
UM0129480 7μM R02 exp85	2.23
GSK-J4 1.5μM R08 exp441	2.35
AICAR 240μM R03 exp116	2.36
Monensin 0.3μM R08 exp507	2.37
R-DABN 8μM R03 exp111	2.44
Artemisinin 50μM R08 exp450	3.47

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TPK catalytic
TPK B1 binding

thiamine binding
thiamine diphosphokinase activity
thiamine diphosphate biosynthetic process
thiamine diphosphate metabolic process
thiamine metabolic process
thiamine-containing compound metabolic process
pyrimidine-containing compound biosynthetic process
kinase activity
water-soluble vitamin metabolic process
pyrimidine-containing compound metabolic process
vitamin metabolic process
coenzyme biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
sulfur compound metabolic process
cofactor metabolic process
drug metabolic process
organophosphate biosynthetic process
organophosphate metabolic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process