TPPP

Entrez Summary: N/A
UniProt Summary: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microtubule bundle
microtubule polymerization
microtubule polymerization or depolymerization
tubulin binding
protein polymerization
microtubule bundle formation
positive regulation of protein polymerization
regulation of protein polymerization
microtubule binding
positive regulation of protein complex assembly
microtubule
regulation of protein complex assembly
supramolecular fiber organization
microtubule cytoskeleton organization
positive regulation of cellular component biogenesis
microtubule-based process
perinuclear region of cytoplasm
cellular protein-containing complex assembly
regulation of cellular component biogenesis
cytoskeleton organization
positive regulation of cellular component organization
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization