TPST1

Entrez Summary: N/A
UniProt Summary: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. {ECO:0000269|PubMed:28821720, ECO:0000269|PubMed:9501187, ECO:0000269|PubMed:9733778}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptidyl-tyrosine sulfation
protein-tyrosine sulfotransferase activity
protein sulfation
sulfation
3-phosphoadenosine 5-phosphosulfate metabolic process
purine ribonucleoside bisphosphate metabolic process
integral component of Golgi membrane
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
peptidyl-tyrosine modification
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
inflammatory response
nucleobase-containing small molecule metabolic process
Golgi membrane
protein homodimerization activity
peptidyl-amino acid modification
organophosphate metabolic process
Golgi apparatus
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
defense response
small molecule metabolic process
membrane