TPTE

Entrez Summary: This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
UniProt Summary: Could be involved in signal transduction.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.98
Lapatinib 5μM R01 exp47	-1.95
Celastrol 0.12μM R05 exp225	-1.81
CB-5083 0.4μM R08 exp468	-1.76

protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
dephosphorylation