TRABD2A

Entrez Summary: N/A
UniProt Summary: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269|PubMed:22726442}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rifampicin 30μM R08 exp430	1.72
Lead acetate 2000μM R08 exp498 no dilution day6	1.75

regulation of protein oxidation
positive regulation of protein oxidation
integral component of organelle membrane
positive regulation of protein oligomerization
Wnt-protein binding
regulation of protein oligomerization
endopeptidase activity
metalloendopeptidase activity
negative regulation of Wnt signaling pathway
positive regulation of protein complex assembly
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of protein complex assembly
positive regulation of cellular component biogenesis
head development
regulation of cellular component biogenesis
cell-cell signaling
positive regulation of cellular component organization
positive regulation of protein modification process
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
integral component of plasma membrane
positive regulation of cellular protein metabolic process
negative regulation of response to stimulus
positive regulation of protein metabolic process
regulation of protein modification process
membrane