TRAF3IP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAF3IP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAF3IP1
  * **<color #00a2e8>Official Name</color>**: TRAF3 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26146|26146]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDR0|Q8TDR0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAF3IP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAF3IP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:12935900, ECO:0000269|PubMed:26487268}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP-T3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|negative regulation of interferon-beta production|
|post-anal tail morphogenesis|
|intraciliary transport particle B|
|negative regulation of defense response to virus|
|negative regulation of embryonic development|
|ciliary transition zone|
|negative regulation of smoothened signaling pathway|
|neural tube patterning|
|ciliary base|
|embryonic camera-type eye development|
|intraciliary transport involved in cilium assembly|
|morphogenesis of a polarized epithelium|
|negative regulation of type I interferon production|
|ciliary tip|
|regulation of interferon-beta production|
|intraciliary transport|
|embryonic digit morphogenesis|
|protein transport along microtubule|
|microtubule-based protein transport|
|regulation of defense response to virus|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|negative regulation of response to biotic stimulus|
|axoneme|
|negative regulation of immune effector process|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|regulation of type I interferon production|
|regulation of embryonic development|
|negative regulation of protein complex assembly|
|ciliary basal body|
|limb morphogenesis|
|appendage morphogenesis|
|transport along microtubule|
|neural tube development|
|cytoskeleton-dependent intracellular transport|
|appendage development|
|limb development|
|microtubule-based transport|
|regulation of microtubule cytoskeleton organization|
|cilium|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|regulation of microtubule-based process|
|microtubule binding|
|protein-containing complex localization|
|kidney development|
|microtubule-based movement|
|negative regulation of cytokine production|
|renal system development|
|negative regulation of nervous system development|
|camera-type eye development|
|urogenital system development|
|regionalization|
|cilium assembly|
|eye development|
|visual system development|
|negative regulation of response to external stimulus|
|sensory system development|
|cilium organization|
|negative regulation of protein phosphorylation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|regulation of immune effector process|
|centrosome|
|regulation of response to biotic stimulus|
|heart development|
|regulation of cytoskeleton organization|
|sensory organ development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|microtubule-based process|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|tube development|
|circulatory system development|
|regulation of nervous system development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|embryo development|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3830
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAF3IP1 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>