TRAF3IP1

Entrez Summary: The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017].
UniProt Summary: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:12935900, ECO:0000269|PubMed:26487268}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
negative regulation of interferon-beta production
post-anal tail morphogenesis
intraciliary transport particle B
negative regulation of defense response to virus
negative regulation of embryonic development
ciliary transition zone
negative regulation of smoothened signaling pathway
neural tube patterning
ciliary base
embryonic camera-type eye development
intraciliary transport involved in cilium assembly
morphogenesis of a polarized epithelium
negative regulation of type I interferon production
ciliary tip
regulation of interferon-beta production
intraciliary transport
embryonic digit morphogenesis
protein transport along microtubule
microtubule-based protein transport
regulation of defense response to virus
embryonic heart tube development
regulation of smoothened signaling pathway
negative regulation of response to biotic stimulus
axoneme
negative regulation of immune effector process
embryonic limb morphogenesis
embryonic appendage morphogenesis
regulation of type I interferon production
regulation of embryonic development
negative regulation of protein complex assembly
ciliary basal body
limb morphogenesis
appendage morphogenesis
transport along microtubule
neural tube development
cytoskeleton-dependent intracellular transport
appendage development
limb development