TRAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAP1
  * **<color #00a2e8>Official Name</color>**: TNF receptor associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10131|10131]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12931|Q12931]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606219|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HATPase c|
|HSP90|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translational attenuation|
|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|negative regulation of cellular respiration|
|negative regulation of hydrogen peroxide-mediated programmed cell death|
|regulation of hydrogen peroxide-mediated programmed cell death|
|negative regulation of response to reactive oxygen species|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of cellular response to drug|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of reactive oxygen species biosynthetic process|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of response to drug|
|regulation of cellular respiration|
|tumor necrosis factor receptor binding|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|negative regulation of reactive oxygen species metabolic process|
|chaperone-mediated protein folding|
|regulation of oxidative stress-induced cell death|
|regulation of cellular response to oxidative stress|
|mitochondrial intermembrane space|
|regulation of response to oxidative stress|
|regulation of reactive oxygen species biosynthetic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of response to drug|
|unfolded protein binding|
|regulation of generation of precursor metabolites and energy|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of reactive oxygen species metabolic process|
|negative regulation of apoptotic signaling pathway|
|protein folding|
|regulation of translation|
|mitochondrial matrix|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|regulation of cellular amide metabolic process|
|protein kinase binding|
|negative regulation of intracellular signal transduction|
|posttranscriptional regulation of gene expression|
|regulation of cellular response to stress|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2242
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAP1 Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>