TRAP1

Gene Information

Official Symbol: TRAP1
Official Name: TNF receptor associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 10131
UniProt: Q12931
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
UniProt Summary: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2242
Expression level (log2 read counts): 7.71

Expression Distribution

HATPase c
HSP90

translational attenuation
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
negative regulation of cellular respiration
negative regulation of hydrogen peroxide-mediated programmed cell death
regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of response to reactive oxygen species
negative regulation of hydrogen peroxide-induced cell death
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of cellular response to drug
regulation of hydrogen peroxide-induced cell death
negative regulation of reactive oxygen species biosynthetic process
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of response to drug
regulation of cellular respiration
tumor necrosis factor receptor binding
regulation of response to reactive oxygen species
regulation of cellular response to drug
negative regulation of oxidative stress-induced cell death
negative regulation of cellular response to oxidative stress
negative regulation of response to oxidative stress
negative regulation of reactive oxygen species metabolic process
chaperone-mediated protein folding
regulation of oxidative stress-induced cell death
regulation of cellular response to oxidative stress
mitochondrial intermembrane space
regulation of response to oxidative stress
regulation of reactive oxygen species biosynthetic process
negative regulation of intrinsic apoptotic signaling pathway
regulation of response to drug
unfolded protein binding
regulation of generation of precursor metabolites and energy
regulation of intrinsic apoptotic signaling pathway
regulation of reactive oxygen species metabolic process
negative regulation of apoptotic signaling pathway
protein folding
regulation of translation
mitochondrial matrix
mitochondrial inner membrane
regulation of apoptotic signaling pathway