TRAPPC2
Gene Information
- Official Symbol: TRAPPC2
- Official Name: trafficking protein particle complex 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6399
- UniProt: P0DI81
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010].
- UniProt Summary: Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3467
- Expression level (log2 read counts): 5.31
TRAPPC2 Expression in NALM6 Cells: 5.31
