TRAPPC2L [The Human Chemical-Genetic Interaction Map Project]

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======= TRAPPC2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC2L
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 2 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51693|51693]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL33|Q9UL33]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:19416478}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sybindin|
|Sedlin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAPP complex|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|protein complex oligomerization|
|organelle localization|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|membrane organization|
|endoplasmic reticulum|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.27|
|[[:results:exp539|42°C R08 exp539]]|-2.25|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.14|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.93|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.91|
|[[:results:exp303|39°C R06 exp303]]|-1.7|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.72|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.72|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.75|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.8|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.81|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.81|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.82|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.89|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.89|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.97|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.08|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.11|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.19|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.23|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.24|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.25|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.26|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.29|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.6|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dync1i2|DYNC1I2]]|0.452|
|[[:human genes:v:vps54|VPS54]]|0.438|
|[[:human genes:n:napa|NAPA]]|0.436|
|[[:human genes:t:trappc11|TRAPPC11]]|0.435|
|[[:human genes:c:cmya5|CMYA5]]|0.41|
|[[:human genes:c:copg1|COPG1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2222
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC2L Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>