TRAPPC2L

Entrez Summary: N/A
UniProt Summary: May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:19416478}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol A 100μM R06 exp269	-2.27
42°C R08 exp539	-2.25
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.14
CB-5083 0.4μM R08 exp468	-1.93
Cannabidiol 20μM R08 exp466	-1.91
39°C R06 exp303	-1.7
Erlotinib 10μM R05 exp216	1.72
IL-3 9ng/ml R08 exp493	1.72
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.75
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.8
Vincristine 0.0005μM R04 exp190	1.8
Chloramphenicol 2μM R00 exp12	1.81
Cyclosporin-A 0.8μM R07 exp347	1.81
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.82
Bortezomib 0.005μM R00 exp6	1.89
CCCP 0.1μM R00 exp10	1.89
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.97
IU1-C 25μM R04 exp183	2
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.08
5-Fluorouracil 2μM R00 exp1	2.11
TRAIL 5ng/ml R00 exp35	2.19
Colchicine 0.009μM R05 exp215	2.23
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.24
Thapsigargin 0.005μM R07 exp407	2.25
Alpha-Amanitin 0.5μM R00 exp5	2.26
Rifampicin 1μM R00 exp31	2.29
CCCP 1μM R00 exp11	2.6
TRAIL 50ng/ml R00 exp36	2.66

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sybindin
Sedlin N

TRAPP complex
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
vesicle organization
establishment of organelle localization
Golgi vesicle transport
protein complex oligomerization
organelle localization
Golgi membrane
intracellular membrane-bounded organelle
perinuclear region of cytoplasm
membrane organization
endoplasmic reticulum
intracellular transport
protein-containing complex assembly
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport