TRAPPC8 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAPPC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC8
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22878|22878]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2L5|Q9Y2L5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614136|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. {ECO:0000269|PubMed:21525244}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAPPC-Trs85|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAPPIII protein complex|
|protein localization by the Cvt pathway|
|autophagy of peroxisome|
|protein localization to phagophore assembly site|
|TRAPP complex|
|phagophore assembly site|
|protein localization to vacuole|
|autophagosome assembly|
|autophagosome organization|
|vacuole organization|
|Golgi organization|
|macroautophagy|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|cytoplasmic vesicle|
|autophagy|
|process utilizing autophagic mechanism|
|Golgi vesicle transport|
|endomembrane system organization|
|protein localization to organelle|
|organelle assembly|
|intracellular transport|
|cellular protein localization|
|cellular macromolecule localization|
|cellular catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.6|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.15|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.1|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.09|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.06|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.97|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.87|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.84|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.93|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.08|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.13|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.563|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:v:vps54|VPS54]]|0.459|
|[[:human genes:t:trappc11|TRAPPC11]]|0.445|
|[[:human genes:o:ogfr|OGFR]]|0.432|
|[[:human genes:v:vps52|VPS52]]|0.426|
|[[:human genes:a:aatf|AATF]]|0.425|
|[[:human genes:c:copb1|COPB1]]|0.425|
|[[:human genes:t:tyms|TYMS]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.422|
|[[:human genes:u:utp20|UTP20]]|0.418|
|[[:human genes:c:cdc45|CDC45]]|0.416|
|[[:human genes:t:tfip11|TFIP11]]|0.414|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 630/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|23/28|
|bone|25/26|
|breast|26/33|
|central nervous system|43/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|18/21|
|liver|17/20|
|lung|57/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC8 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>