TRIB1 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIB1
  * **<color #00a2e8>Official Name</color>**: tribbles pseudokinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10221|10221]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RU8|Q96RU8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2- dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). {ECO:0000250|UniProtKB:Q8K4K4, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797, ECO:0000305|PubMed:27041596}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of eosinophil differentiation|
|negative regulation of neutrophil differentiation|
|positive regulation of eosinophil differentiation|
|regulation of neutrophil differentiation|
|ubiquitin-protein transferase regulator activity|
|positive regulation of granulocyte differentiation|
|negative regulation of granulocyte differentiation|
|mitogen-activated protein kinase kinase binding|
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|positive regulation of macrophage differentiation|
|regulation of granulocyte differentiation|
|regulation of macrophage differentiation|
|negative regulation of smooth muscle cell migration|
|regulation of lipopolysaccharide-mediated signaling pathway|
|protein kinase inhibitor activity|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of myeloid leukocyte differentiation|
|positive regulation of myeloid leukocyte differentiation|
|regulation of smooth muscle cell migration|
|negative regulation of myeloid cell differentiation|
|JNK cascade|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of myeloid cell differentiation|
|negative regulation of response to biotic stimulus|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of leukocyte differentiation|
|positive regulation of proteasomal protein catabolic process|
|stress-activated MAPK cascade|
|regulation of myeloid leukocyte differentiation|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of smooth muscle cell proliferation|
|negative regulation of hemopoiesis|
|positive regulation of cellular protein catabolic process|
|stress-activated protein kinase signaling cascade|
|positive regulation of leukocyte differentiation|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of DNA-binding transcription factor activity|
|regulation of proteasomal protein catabolic process|
|positive regulation of hemopoiesis|
|negative regulation of multi-organism process|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|protein kinase activity|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cell migration|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|ubiquitin protein ligase binding|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|transcription factor binding|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|negative regulation of response to external stimulus|
|MAPK cascade|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|response to bacterium|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.76|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.578|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9808
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIB1 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>