TRIB1

Gene Information

Official Symbol: TRIB1
Official Name: tribbles pseudokinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 10221
UniProt: Q96RU8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2- dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). {ECO:0000250|UniProtKB:Q8K4K4, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797, ECO:0000305|PubMed:27041596}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9808
Expression level (log2 read counts): 5.55

Expression Distribution

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	1.76
Sulforaphane 9μM R08 exp525	1.86

Pkinase Tyr
Pkinase

regulation of eosinophil differentiation
negative regulation of neutrophil differentiation
positive regulation of eosinophil differentiation
regulation of neutrophil differentiation
ubiquitin-protein transferase regulator activity
positive regulation of granulocyte differentiation
negative regulation of granulocyte differentiation
mitogen-activated protein kinase kinase binding
negative regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of macrophage differentiation
regulation of granulocyte differentiation
regulation of macrophage differentiation
negative regulation of smooth muscle cell migration
regulation of lipopolysaccharide-mediated signaling pathway
protein kinase inhibitor activity
negative regulation of smooth muscle cell proliferation
negative regulation of myeloid leukocyte differentiation
positive regulation of myeloid leukocyte differentiation
regulation of smooth muscle cell migration
negative regulation of myeloid cell differentiation
JNK cascade
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of myeloid cell differentiation
negative regulation of response to biotic stimulus
positive regulation of ubiquitin-dependent protein catabolic process
negative regulation of leukocyte differentiation
positive regulation of proteasomal protein catabolic process
stress-activated MAPK cascade
regulation of myeloid leukocyte differentiation
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of smooth muscle cell proliferation
negative regulation of hemopoiesis
positive regulation of cellular protein catabolic process
stress-activated protein kinase signaling cascade
positive regulation of leukocyte differentiation
regulation of ubiquitin-dependent protein catabolic process
negative regulation of DNA-binding transcription factor activity
regulation of proteasomal protein catabolic process
positive regulation of hemopoiesis