TRIM16 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM16
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10626|10626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95361|O95361]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609505|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the regulation of keratinocyte differentiation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NACHT domain binding|
|positive regulation of retinoic acid receptor signaling pathway|
|interleukin-1 binding|
|positive regulation of keratinocyte differentiation|
|regulation of retinoic acid receptor signaling pathway|
|positive regulation of epidermal cell differentiation|
|positive regulation of interleukin-1 beta secretion|
|response to growth hormone|
|positive regulation of interleukin-1 secretion|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|histone H3 acetylation|
|regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|histone H4 acetylation|
|positive regulation of interleukin-1 production|
|positive regulation of epithelial cell differentiation|
|transferase activity|
|regulation of epidermal cell differentiation|
|regulation of interleukin-1 beta production|
|regulation of epidermis development|
|regulation of interleukin-1 production|
|PML body|
|response to retinoic acid|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|response to organophosphorus|
|positive regulation of cytokine secretion|
|regulation of epithelial cell differentiation|
|protein acetylation|
|protein acylation|
|regulation of cytokine secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|peptidyl-lysine modification|
|response to acid chemical|
|histone modification|
|covalent chromatin modification|
|response to peptide hormone|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|response to peptide|
|regulation of peptide secretion|
|regulation of cytokine production|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|zinc ion binding|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|positive regulation of cell differentiation|
|positive regulation of transport|
|response to organonitrogen compound|
|regulation of protein localization|
|chromosome organization|
|response to nitrogen compound|
|positive regulation of developmental process|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.43|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.88|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.71|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.71|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9171
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM16 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>