TRIM16
Gene Information
- Official Symbol: TRIM16
- Official Name: tripartite motif containing 16
- Aliases and Previous Symbols: N/A
- Entrez ID: 10626
- UniProt: O95361
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in the regulation of keratinocyte differentiation.
Pfam Domains GO Terms
Pfam Domains
| SPRY |
| zf-B box |
GO Terms
| NACHT domain binding |
| positive regulation of retinoic acid receptor signaling pathway |
| interleukin-1 binding |
| positive regulation of keratinocyte differentiation |
| regulation of retinoic acid receptor signaling pathway |
| positive regulation of epidermal cell differentiation |
| positive regulation of interleukin-1 beta secretion |
| response to growth hormone |
| positive regulation of interleukin-1 secretion |
| positive regulation of epidermis development |
| regulation of keratinocyte differentiation |
| histone H3 acetylation |
| regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-1 secretion |
| histone H4 acetylation |
| positive regulation of interleukin-1 production |
| positive regulation of epithelial cell differentiation |
| transferase activity |
| regulation of epidermal cell differentiation |
| regulation of interleukin-1 beta production |
| regulation of epidermis development |
| regulation of interleukin-1 production |
| PML body |
| response to retinoic acid |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| response to organophosphorus |
| positive regulation of cytokine secretion |
| regulation of epithelial cell differentiation |
| protein acetylation |
| protein acylation |
| regulation of cytokine secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| peptidyl-lysine modification |
| response to acid chemical |
| histone modification |
| covalent chromatin modification |
| response to peptide hormone |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| response to peptide |
| regulation of peptide secretion |
| regulation of cytokine production |
| chromatin organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| zinc ion binding |
| response to lipid |
| peptidyl-amino acid modification |
| response to hormone |
| positive regulation of cell differentiation |
| positive regulation of transport |
| response to organonitrogen compound |
| regulation of protein localization |
| chromosome organization |
| response to nitrogen compound |
| positive regulation of developmental process |
| DNA binding |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mitomycin-C 0.06μM R08 exp503 | -2.43 |
| Chloramphenicol 20μM R00 exp13 | -1.88 |
| Apcin 50 to 100μM on day4 R04 exp176 | -1.71 |
| Vitamin-D3 40μM R08 exp536 | 1.71 |
| Chloroquine 32μM R08 exp470 | 1.76 |
| SNS-032 15μM R08 exp443 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9171
- Expression level (log2 read counts): 4.2
Expression Distribution
TRIM16 Expression in NALM6 Cells: 4.2
